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2024 Sep 1;16(9):e68390

Although the direct conjugation of -lactams with GSH is not well-documented, GSH plays a crucial role in maintaining a reducing environment in the cytosol, which is essential for proper enzyme function

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doi: 10.1016/j.jad.2023.05.009 31

Along with RAAS inhibitors, these therapies are increasingly regarded as foundational components of DKD management [19,133]

The peptide incorporates two key structural modifications: (i) substitution of alanine with 2-aminoisobutyric acid (Aib) at position 8 , which confers resistance to dipeptidyl peptidase-4 (DPP-4) degradation and extends peptide stability in vivo